Major research interests are the development of asymmetric organic catalyst and its application to asymmetric reaction, total synthesis of biologically important molecules, chemical biology based on natural product and functional organic compounds. In details, my group develops various catalysts including chiral cation organocatalyst, DMAP based organocatalyst, chiral NHC catalyst and chiral combined Lewis acid catalyst. With these catalysts, my group studies new catalytic asymmetric reaction. For examples, asymmetric one-pot multicomponent reaction, asymmetric C-H, C-C functionalization, asymmetric Diels-Alder reaction and so on. With developed synthetic methodology, my group synthesizes useful bioactive natural products and its derivatives or functional organomaterials.
Journal Articles
(2024)
CatalyticAsymmetricFormalC−C Bond InsertionReactionofAldehydesvia 1,2-AcylShift: Constructionof All-CarbonQuaternaryStereocenterswith Three CarbonylGroups.
ACS CATALYSIS.
14,
1
(2023)
Asymmetric Catalysis with Chiral Oxazaborolidinium Ions (COBIs):from
Cyclization to Radical Reactions.
ALDRICHIMICA ACTA.
56,
1
(2023)
Enantioselective Friedel−Crafts Reaction of Heteroaromatic
Compounds with Glyoxals Catalyzed by Chiral Oxazaborolidinium
Ion Catalyst.
ORGANIC LETTERS.
25,
25
(2022)
Enantio- and Diastereoselective Michael Addition of Cyclic Ketones/ Aldehydes to Nitroolefins in Water as Catalyzed by Proline-Derived Bifunctional Organocatalysts.
JOURNAL OF ORGANIC CHEMISTRY.
87,
24
(2022)
Strecker Reactions of Formaldehyde with TMSCN, Catalyzed by TBAF and Formic Acid: N-Monocyanomethylation of Primary Amines.
ADVANCED SYNTHESIS & CATALYSIS.
365,
1
(2022)
Visible Light-Mediated Enantioselective Addition of alpha-Aminoalkyl Radicals to Ketones Catalyzed by Chiral Oxazaborolidinium Ion.
JOURNAL OF ORGANIC CHEMISTRY.
87,
16
(2022)
Enantioselective Friedel-Crafts Alkylation of Furans with o-Quinone Methide Using a Chiral Oxazaborolidinium Ion Catalyst.
ORGANIC LETTERS.
24,
8
(2021)
Ternary Electron Donor-Acceptor Complex Enabled Enantioselective Radical Additions to alpha, beta-Unsaturated Carbonyl Compounds.
ACS CATALYSIS.
11,
24
(2021)
Catalytic Asymmetric Darzens-Type Epoxidation of Diazoesters: Highly Enantioselective Synthesis of Trisubstituted Epoxides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
60,
41
(2021)
A Mild Method for Access to alpha-Substituted Dithiomalonates through C-Thiocarbonylation of Thioester: Synthesis of Mesoionic Insecticides.
ADVANCED SYNTHESIS & CATALYSIS.
363,
13
(2021)
Kinetic Resolution and Dynamic Kinetic Resolution of gamma-Aryl-Substituted Butenolides via Copper-Catalyzed 1,4-Hydroboration.
ADVANCED SYNTHESIS & CATALYSIS.
363,
9
(2021)
Bifunctional Urea/Hg(OAc)(2)-Mediated Synthesis of 4-Aryl-6(-)oxycarbonyl-2-pyrones and 2-Pyridones from Dithiomalonate and beta,gamma-Unsaturated alpha-Keto Esters.
JOURNAL OF ORGANIC CHEMISTRY.
86,
8
(2021)
Asymmetric Synthesis of (-)-Dictyopterene C ' and its Derivatives via Catalytic Enantioselective Cyclopropanation.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY.
42,
4
(2021)
Enantioselective Acyloin Rearrangement of Acyclic Aldehydes Catalyzed by Chiral Oxazaborolidinium Ion.
ORGANIC LETTERS.
23,
4
(2021)
Design and Synthesis of 5-Aryl-substituted Phenylpyrimidine-2,4-diamine Derivatives as Novel Mer and Tyro3 Kinase Inhibitors.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY.
42,
2
(2021)
Comparable Plasma Lipid Changes in Patients with High-Grade Cervical Intraepithelial Neoplasia and Patients with Cervical Cancer.
JOURNAL OF PROTEOME RESEARCH.
20,
1
(2020)
Circulating lipidomic alterations in obese and non-obese subjects with non-alcoholic fatty liver disease.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS.
52,
10
Publications
(2022)
Furans and Furan Derivatives - Recent Advances and Applications.
IntechOpen.
Lead author
사각 탄소 고리 케톤 화합물 및 이의 합성 방법.
10-2018-0173953.
20200708.
KOREA, REPUBLIC OF
2차 아릴 알코올 및 이의 합성 방법.
10-2018-0142797.
20200313.
KOREA, REPUBLIC OF
화합물, 이를 이용하는 비대칭 마이클 첨가 반응을
이용한 화합물의 제조 방법, 및 페니버트 화합물의 제조
방법.
10-2016-0117923.
20180717.
KOREA, REPUBLIC OF
α-아릴-β-하이드록시 와인렙 아마이드의 합성 방법.
10-2016-0016038.
20180102.
KOREA, REPUBLIC OF
α-아릴-β-하이드록시 와인렙 아마이드의 합성 방법.
10-2016-0016038 .
20180102.
KOREA, REPUBLIC OF
아릴 다이아조알켄을 이용한 비대칭 촉매 탄소-수소 결합 삽입반응의 개발: 광학활성을 지닌 비고리형 알파-삼차 아릴 케톤의 합성.
10-2015-0165713.
20170906.
KOREA, REPUBLIC OF
신규한 베타 치환된 모리타-베일리스-힐만 유도체.
1020080020935.
20150410.
KOREA, REPUBLIC OF
싸이클릭 이논의 베타-바이닐 탄소-수소 결합의 입체선택적 기능화 반응.
10-2013-0108853.
20150210.
KOREA, REPUBLIC OF
알파 알킬 베타 키토 에스터 화합물의 입체선택적 합성 : 옥사자보로리디늄 이온을 이용한 비대칭 로스캄프 반응.
10-2012-0133221 .
20141122.
KOREA, REPUBLIC OF
옥사자보롤리듐 이온에 의한 비대칭 로스캄프 반응.
10-2014-0086196.
20141114.
KOREA, REPUBLIC OF
신규한 베타 치환된 모리타-베일리스-힐만 에스테르의 입체선택적인 합성방법.
10-2009-0050500.
20101216.
KOREA, REPUBLIC OF
Conference Paper
(2022)
Catalytic Asymmetric Aldehyde Addition-Rearrangements
of Diazo esters.
The 15th International Conference on Cutting-Edge Organic Chemistry in Asia.
HONG KONG
(2021)
Enantioselective Epoxidation of Aldehyde with Aryl Diazo Ester:
Synthesis of Chiral Tri-Substituted Epoxide.
128th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2021)
Catalytic Enantioselective Acyloin Rearrangement of Aldehydes Using
Chiral Oxazaborolidinium Ion.
127th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2021)
Enantioselective epoxidation with diazo ester catalyzed by chiral Lewis
acid catalyst..
127th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2020)
Enantioselective Domino Reactions of Diazo Compounds
Catalyzed by COBI.
Chiral India 2020, 9th International Conference.
INDIA
(2020)
Chiral Lewis Acid Catalyzed Visible-Light Photoredox Initiated Enantioselective Radical 1,2-Addition.
2020 제 22 회 한국유기합성학회학술대회(추계학술대회).
KOREA, REPUBLIC OF
(2020)
Chiral Boron-based Lewis Acid Catalyzed Enantioselective Radical
1,2-Addition to Aldehydes.
126th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2020)
Lewis Acid Catalyzed Tandem Reactions Using ortho-Quinone
methides..
126th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2020)
Catalytic Asymmetric Methallylation and Allylation Reactions of
Aldehydes with Silanes : Using a Chiral Lewis Acid.
125th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2020)
Chiral Lewis Acid Catalyzed Asymmetric Synthesis of β-Amino Alcohols via Dual Catalysts.
125th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2020)
Enantioselective Synthesis of 2-Aryl-2,3-Dihydrobenzofurans by Lewis Acid Catalyzed Tandem Reactions..
125th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2019)
Enantioselective Carbonyl Addition Reactions of Diazo Compounds Catalyzed by COBI.
2019 International Symposium for Convergence of Nano-based Science & Technology.
KOREA, REPUBLIC OF
(2019)
Enantioselective Carbonyl 1,2- or 1,4-Addition Reactions of Nucleophilic Silyl and Diazo Compounds Catalyzed by COBI.
9th China-Korea Symposium on Organic Chemistry.
CHINA
(2019)
Enantioselective Radical Addition to Various Aldehydes Using Lewis Acid and Photoredox Catalyst.
124th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2019)
Catalytic Asymmetric Cyclopropanation of Diazo Compounds
and Tandem Molecular Rearrangement.
14th ICCEOCA-14/ACP2019.
JAPAN
(2019)
Synthesis of Bioactive Compounds via Catalytic Asymmetric Cyclopropanation.
8th Changbai, Mountain Forum.
CHINA
(2019)
Asymmetric Synthesis of β-Amino Alcohols using Acrolein Derivatives.
2019 춘계대한화학회 학술총회.
KOREA, REPUBLIC OF
(2019)
Enantioselective Strecker reaction of Aldimines Activated by Chiral
Oxazaborolidinium Ion with Trimethylsilyl Cyanide.
123rd General Meeting of Korean Chemical Society.
KOREA, REPUBLIC OF
(2019)
Enantioselective [4+1]-Cycloannulation of ortho-Quinone Methides with Diazoesters.
123rd General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2018)
Catalytic Asymmetric Synthesis of Cyclobutanones via Tandem Cyclopropanation/SemiPinacol Rearrangement.
2018 대한화학회 추계총회.
KOREA, REPUBLIC OF
